Non-smokers are also suffering from lung cancer

The close relationship between tobacco and lung cancer, but why do some people never smokers also suffering from lung cancer? recently, Chinese Academy of Sciences Institute of Biochemistry and cell and Fudan University Cancer Hospital in non-smokers lung adenocarcinoma patients tumor sample source, first discovered the existence of the key cancer gene.

It is these gene mutation that causes the lung adenocarcinoma.

From the perspective of the pathology in lung cancer can generally be divided into small cell lung cancer and non-small cell lung cancer, which in turn can be broken down into cancer, squamous cell carcinoma and large cell carcinoma.

At present, various lung adenocarcinoma is a subtype of the most common, at the annual global confirmed new cases accounted for about 40%.

As early as the 1950s, people have come to realize the relationship between smoking and lung cancer, small cell lung cancer and smoking the most intimate of relationships.

The study found that over 90% of patients with small cell lung cancer from smoking, and 75% of squamous cell carcinoma from the smoking population, by contrast, only 50% of lung adenocarcinoma patients are smokers.

Based on the lung adenocarcinoma in China's high-fat, from the non-smokers ' lung adenocarcinoma patients already are multilingual but also non-smoking and lung cancer patients, the majority of women.

Therefore, in the non-smokers ' lung cancer has become a kind of disease. The researchers pointed out that, if you know what gene mutation and cancer development, clinical it is possible to selectively to patients with specific targeted therapy. Revealing the non-smoking and lung cancer among key cancer gene mutation spectrum will provide clinical targeted therapy theory and new policies.

Institute of Biochemistry and cell the quarter red bin, researcher and Fudan University Cancer Hospital Prof. Chen haiquan thoracic surgery, in establishing high-quality sample libraries with lung cancer, based on the analysis of non-smokers lung adenocarcinoma patient sources of cancer-causing gene in samples from key mutations.

Study results show that in 52 cases of non-smokers lung adenocarcinoma patient sources of tumor samples, 90% there is a cancer gene mutation or integration. Among them there are 41 cases of EGFR kinase domain mutations, 2 cases have HER2 protein kinase domain mutations, 3 cases have EML4-ALK gene fusion, 1 case with KRAS gene mutation. The research results published in renowned journals of the journal of Clinical Oncology.

(Edit: Justin Lin, internships)